Structure of PDB 6lqm Chain M Binding Site BS02

Receptor Information

>6lqm Chain M (length=86) Species: 9606 (Homo sapiens)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

Ligand information

>6lqm Chain 8 (length=156)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcu

.........................................<<<<<<<<<
....>>>>.....<.<<<......>>.............>>>..>...>>
>....<<....>><<<<<<<<.......>>>>>>>>..............
......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6lqm Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.
• Resolution: 3.09 Å
• Binding residue (original residue number in PDB): R20 R21 G23 Y39 K42 T59 G62 R63 M64 R65 H66 R72 F74 H76 R79 G81 T82 P84 P86
• Binding residue (residue number reindexed from 1): R19 R20 G22 Y38 K41 T58 G61 R62 M63 R64 H65 R71 F73 H75 R78 G80 T81 P83 P85

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding
• GO:0097371 MDM2/MDM4 family protein binding
• GO:1990948 ubiquitin ligase inhibitor activity

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:1901798 positive regulation of signal transduction by p53 class mediator

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6lqm, PDBe:6lqm, PDBj:6lqm
• PDBsum: 6lqm
• PubMed: 32669547
• UniProt: P61927|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)