Structure of PDB 6la8 Chain M Binding Site BS02

Receptor Information
>6la8 Chain M (length=106) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEI
LELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQ
AVLLPK
Ligand information
>6la8 Chain J (length=349) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctggttttttttttcatgtgccggtctcacacgtgcctggagactagt
aagcgcttctagtggcggttaaaacgcggtagacagcgcgtacgtgcgtt
taagcggtgctagagctgtctacgaccaattgagcggcctcggcaccggg
atgcgttttttttttcatactcgagcatgcttttttttttcatgtgccgg
tctcacacgtgcctggagactagtaagcgcttctagtggcggttaaaacg
cggtagacagcgcgtacgtgcgtttaagcggtgctagagctgtctacgac
caattgagcggcctcggcaccgggatgcgttttttttttccagcggtac
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6la8 Near-atomic resolution structures of interdigitated nucleosome fibres.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R29 R42 V43 A45 K75 T76 R77
Binding residue
(residue number reindexed from 1)		R17 R30 V31 A33 K63 T64 R65
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6la8, PDBe:6la8, PDBj:6la8
PDBsum6la8
PubMed32958761
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

[Back to BioLiP]