Structure of PDB 6hkt Chain M Binding Site BS02

Receptor Information
>6hkt Chain M (length=103) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILEL
AGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVL
LPK
Ligand information
>6hkt Chain J (length=1122) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcgctgttcaatacatgcacaggatgtatatatctgacacgtgcctgga
gactagggagtaatccccttggcggttaaaacgcgggggacagcgcgtac
gtgcgtttaagcggtgctagagctgtctacgaccaattgagcggcctcgg
caccgggattctccagggcggccgcgtatagggtctcggggctgttcaat
acatgcacaggatgtatatatctgacacgtgcctggagactagggagtaa
tccccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcg
gtgctagagctgtctacgaccaattgagcggcctcggcaccgggattctc
cagggcggccgcgtatagggtctcggggctgttcaatacatgcacaggat
gtatatatctgacacgtgcctggagactagggagtaatccccttggcggt
taaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctagagctgt
ctacgaccaattgagcggcctcggcaccgggattctccagggcggccgcg
tatagggtctcggggctgttcaatacatgcacaggatgtatatatctgac
acgtgcctggagactagggagtaatccccttggcggttaaaacgcggggg
acagcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaattg
agcggcctcggcaccgggattctccagggcggccgcgtatagggtctcgg
ggctgttcaatacatgcacaggatgtatatatctgacacgtgcctggaga
ctagggagtaatccccttggcggttaaaacgcgggggacagcgcgtacgt
gcgtttaagcggtgctagagctgtctacgaccaattgagcggcctcggca
ccgggattctccagggcggccgcgtatagggtctcggggctgttcaatac
atgcacaggatgtatatatctgacacgtgcctggagactagggagtaatc
cccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggt
gctagagctgtctacgaccaattgagcggcctcggcaccgggattctcca
gggcggccgcgtatagggtgat
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6hkt Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation.
Resolution9.7 Å
Binding residue
(original residue number in PDB)		R29 R42 V43 G44 A45 T76 R77
Binding residue
(residue number reindexed from 1)		R14 R27 V28 G29 A30 T61 R62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hkt, PDBe:6hkt, PDBj:6hkt
PDBsum6hkt
PubMed30392928
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

[Back to BioLiP]