Structure of PDB 6gen Chain M Binding Site BS02

Receptor Information
>6gen Chain M (length=688) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVVDVPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQT
ISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSPQ
QRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKN
FRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTVIDGKKV
SGFAETKKTVAKLHQVLRPYLLRRLKADVEKQMPAKYEHIVYCKLSKRQR
FLYDDFMSRAQTKATLASGNFMSIVNCLMQLRKVCNHPNLFEVRPILTSF
VLEHCVASDYKDVERTLLKLFKKNNQVNRVDLDFLNLVFTLNDKDLTSYH
AEEISKLTCVKNFVEEVNKLRETNKQLQEEFGEASFLNFQDANQYFKYSN
KQKLEGTVDMLNFLKMVNKLRCDRRPIFGKNLIDLLTKDRRVKYDKSSII
DNELIKPLQTRVLDNRKIIDTFAVLTPSAVSLDMRKLALGLNDDSSVGEN
TRLKVMQNCFEVSNPLHQLQTKLTIAFPDKSLLQYDCGKLQKLAILLQQL
KDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERF
NTDSRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRI
GQTRDVHIYRFVSEHTIESNILKKANQKRQLDNVVIQE
Ligand information
>6gen Chain J (length=173) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgcacaggatgtatatatctgacacgtgcctggagactagggagtaatcc
ccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtg
ctagagctgtctacgaccaattgagcggcctcggcaccgggattctccag
ggcggccgcggatgcattaatgc
Receptor-Ligand Complex Structure
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PDB6gen Structure and dynamics of the yeast SWR1-nucleosome complex.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		T754 S779 R787 K788 N791 Q804 L805 Q808 H811 M980 N984 M1271 T1272 G1294 R1322 S1323
Binding residue
(residue number reindexed from 1)		T73 S98 R106 K107 N110 Q123 L124 Q127 H130 M272 N276 M563 T564 G586 R614 S615
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0060090 molecular adaptor activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0000725 recombinational repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005829 cytosol

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gen, PDBe:6gen, PDBj:6gen
PDBsum6gen
PubMed30309918
UniProtQ05471|SWR1_YEAST Helicase SWR1 (Gene Name=SWR1)

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