Structure of PDB 6az3 Chain M Binding Site BS02

Receptor Information
>6az3 Chain M (length=203) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAFMYLNELWKKKSSDVMRFIQRIRSWEFRHQHTVVRLRRPTRPEKARML
GYKTKQGFCVFRVRVRRGGRKRPVHKGITYGKPKTSGVLGMKLNKNNQAV
AEQRLGKRFGNLRVLNSYWVNMDSTFKWYEVIAVDPMCKTIRRDPRINWI
VNSVHKHREQRGLTSAGRKHRGLRHKGHKASKLRPSYRAAWRRNNRIVFL
RKR
Ligand information
>6az3 Chain 2 (length=1078) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguauaucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgagcuucacuuaucgaau
gaagagaccaauggguuuagcguagucuuggcuaugcaccgucuagguuu
ccgugcuguaaacugaaccaacgggaaguuccggagucuuguuucgagac
aucugccagauggggaguuuggcuggggcggcauaucuguuacacgacaa
cgcagguguccuaaggcgagcucagugggaacagaaaucucacguagaac
acaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacu
gcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaa
ucauaccagaggugucagaauaauuaccacagggauaacuggcuuguggc
ggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucu
uccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacu
gacagggaacgugagcuggguuuagaccgucgugagacagguugguuuua
cccuacuuagcuggaaauugcgagaaaaagauuauccguaagcggacgug
cgagcgguggguguacgguacgcucacc
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<...............<<<<
<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<..>>>.>>>...<<<<<.
....<<<<...........<.<<<..........>>>.>...........
.....................<<<<....>>>>..>>>>...>>>>>...
....>>>>>>>..>>>>>...<<<.....>>>..<<<<<<..........
.>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<
......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<
<<....>>>.>>........<<<<<<..............<<<<......
.>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<
<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<
<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>..
...>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>.
.>>>.>>>>>>>......................<<.......>>.<.<>
.>.<.<<.....<<<...>>>..>>.>.
Receptor-Ligand Complex Structure
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PDB6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R31 R67 G69 K72 P74 H76 K77 I79 T80 Y81 G82 V89 L90 K93 S125 T126
Binding residue
(residue number reindexed from 1)		R30 R66 G68 K71 P73 H75 K76 I78 T79 Y80 G81 V88 L89 K92 S124 T125
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6az3, PDBe:6az3, PDBj:6az3
PDBsum6az3
PubMed29150609
UniProtE9BMB4

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