Structure of PDB 5yiz Chain M Binding Site BS02

Receptor Information
>5yiz Chain M (length=94) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPTSLCCKQCQETEITTKNEIFSLSLHETLTVYKASNLNLIGRPSTVHSW
FPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5yiz Chain M Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yiz Structural basis of thalidomide enantiomer binding to cereblon
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C326 C329 C394 C397
Binding residue
(residue number reindexed from 1)		C7 C10 C61 C64
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5yiz, PDBe:5yiz, PDBj:5yiz
PDBsum5yiz
PubMed29358579
UniProtQ8C7D2|CRBN_MOUSE Protein cereblon (Gene Name=Crbn)

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