Structure of PDB 4l0o Chain M Binding Site BS02

Receptor Information
>4l0o Chain M (length=365) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGGYEYSRSGNPTRF
ALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGTFR
LFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDL
AQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDV
VAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQ
KNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKN
DSEAVAFVESLKLFILGESLGGVESLVGIPAFMAGIRDGLVRLSVGIEHE
QDLLEDLEQAFAKIG
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain4l0o Chain O Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4l0o Structure determination of cystathionine gamma-synthase from Helicobacter pylori
Resolution2.76 Å
Binding residue
(original residue number in PDB)		Y44 R46
Binding residue
(residue number reindexed from 1)		Y41 R43
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.48: cystathionine gamma-synthase.
Gene Ontology
Molecular Function
GO:0003962 cystathionine gamma-synthase activity
GO:0004123 cystathionine gamma-lyase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009086 methionine biosynthetic process
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l0o, PDBe:4l0o, PDBj:4l0o
PDBsum4l0o
PubMed
UniProtP56069|METB_HELPY Cystathionine gamma-synthase (Gene Name=metB)

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