Structure of PDB 2wj8 Chain M Binding Site BS02

Receptor Information

>2wj8 Chain M (length=374) Species: 11260 (Human respiratory syncytial virus A strain Long)

ALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGML
LITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHR
QDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRH
DSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLL
PKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAY
GAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFY
HILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAK
AYAEQLKENGVINYSVLDLTAEEL

Ligand information

>2wj8 Chain n (length=7)

ccccccc

.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wj8 Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus
• Resolution: 3.29 Å
• Binding residue (original residue number in PDB): R185 V189 I242
• Binding residue (residue number reindexed from 1): R184 V188 I241

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0030291 protein serine/threonine kinase inhibitor activity

Biological Process

• GO:0019049 virus-mediated perturbation of host defense response
• GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
• GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
• GO:0039554 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
• GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling
• GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade

Cellular Component

• GO:0019013 viral nucleocapsid
• GO:0019028 viral capsid
• GO:0019029 helical viral capsid
• GO:0030430 host cell cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:2wj8, PDBe:2wj8, PDBj:2wj8
• PDBsum: 2wj8
• PubMed: 19965480
• UniProt: P03418|NCAP_HRSVA Nucleoprotein (Gene Name=N)