Structure of PDB 1ycp Chain M Binding Site BS02

Receptor Information
>1ycp Chain M (length=101) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGD
SGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
D
Ligand information
Receptor-Ligand Complex Structure
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PDB1ycp Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		I174 D189 E192 S195 W215 G216 G219
Binding residue
(residue number reindexed from 1)		I25 D45 E48 S51 W73 G74 G76
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ycp, PDBe:1ycp, PDBj:1ycp
PDBsum1ycp
PubMed9307032
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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