Structure of PDB 8xt2 Chain Ll Binding Site BS02

Receptor Information

>8xt2 Chain Ll (length=354) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RRTPPLGPMPNSDIDLSNLERLEKYRSFDRYRRRAEQEAQAPHWWRTYRE
YFGEKTDPKEKIDIGLPPPKVSRTQQLLERKQAIQELRANVEEERAARLR
TASVPLDAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVA
YAVGEDDLMPVYCGNEVTPTEAAQAPEVTYEAEEGSLWTLLLTSLDGHLL
EPDAEYLHWLLTNIPGNRVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQD
QPIDFSEDARPSPCYQLAQRTFRTFDFYKKHQETMTPAGLSFFQCRWDDS
VTYIFHQLLDMREPVFEFVRPPPYHPKQKRFPHRQPLRYLDRYRDSHEPT
YGIY

Ligand information

>8xt2 Chain L2 (length=56) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agaguguagcuuaaaagcacccaacuuacacuuaggagauucaauugacg
cucuga

<<<<<...<<<....>>>.<<.<<.......>>.>>....<<<..>>>.>
>>>>..

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	R52 S53 R56 R99 K107 R114 R126
Binding residue (residue number reindexed from 1)	R26 S27 R30 R73 K81 R88 R100

Gene Ontology

	Molecular Function
GO:0005515	protein binding

	Biological Process
GO:0032543	mitochondrial translation

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005762	mitochondrial large ribosomal subunit
GO:0005829	cytosol
GO:0005840	ribosome
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum	8xt2
PubMed	38942792
UniProt	Q96DV4\|RM38_HUMAN Large ribosomal subunit protein mL38 (Gene Name=MRPL38)

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