Structure of PDB 8rxh Chain Ll Binding Site BS02

Receptor Information
>8rxh Chain Ll (length=50) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRFKPLAVKKKYAKKMNQNKPVPYWIRLRTGNRIKWNEKRRHWRRTKLNY
Ligand information
>8rxh Chain L2 (length=1155) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacuca
gaacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugu
gaugcauccaagugguguauaucgcaaacugauuucugcccagugcucug
aaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaa
cuaugacucucuuaagguagccaaaugccucgucuuccaauuagagacgc
gcaugaauggauuaaugagauucccucugucccgaguuacuaucuagcga
aacgacagucaagggaacggacuugaagggcuaagcggggaaagaagacc
cuguugaguuugacuccagucuggcucugugcggcgacaucugaggcucg
gaacguugcuucacuuaucgaaugaagagaccaauggguuuagcguaguc
uucgggcuaugcaccgucuagguuugggaguccccuguggguacccaacc
gugcuguaaacugaaccaacgggauugcaguuccggagucuuguuucgag
acaucugccagauggggaguuuggcuggggcggcauaucuguuacacgac
aacgcagguguccuaaggcgagcucagugggaacagaaaucucacguaga
acacaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgaga
cugcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaaca
aaucauaccagaggugucagaauaauuaccacagggauaacuggcuugug
gcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcu
cuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguucaccca
cugacagggaacgugagcuggguuuagaccgucgugagacagguugguuu
uacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcgg
acgucgggucguugggccuggcgagcgguggguaguacaugguacgcuca
ucacc
........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>
>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<
....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<..
..<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<.......>>>>>..
...>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>....
........<<<<<........>>>>>..<<<<<<<..<<<.<<......<
<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>
>>..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<
....>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>
...................<<<<<......>>>>>..>>>>...>>>>>.
......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<........
...>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....
<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>
.<<<....>>>.>>.........<<<<<..............<<<<....
...>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<
<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.
<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>
>..>>>.>>>>>>>.......................<<<<.....>>>>
.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>
>>.>.
Receptor-Ligand Complex Structure
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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		R3 K5 L7 K10 W44 R45
Binding residue
(residue number reindexed from 1)		R2 K4 L6 K9 W43 R44
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4QEQ0

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