Structure of PDB 6zmo Chain Ll Binding Site BS02

Receptor Information

>6zmo Chain Ll (length=50) Species: 9606 (Homo sapiens)

SSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL

Ligand information

>6zmo Chain L8 (length=156)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcu

.........................................<<<<<<<<<
....>>>>.....<.<<<......>>.............>>>..>...>>
>....<<....>><<<<<<<<<.....>>>>>>>>>..............
......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zmo Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): F7 K15 K18 Q19 R21 W26 I27 M29 K30 T31 I35
• Binding residue (residue number reindexed from 1): F6 K14 K17 Q18 R20 W25 I26 M28 K29 T30 I34

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0002227 innate immune response in mucosa
• GO:0006412 translation
• GO:0019731 antibacterial humoral response
• GO:0050830 defense response to Gram-positive bacterium
• GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide

Cellular Component

• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zmo, PDBe:6zmo, PDBj:6zmo
• PDBsum: 6zmo
• PubMed: 32680882
• UniProt: P62891|RL39_HUMAN Large ribosomal subunit protein eL39 (Gene Name=RPL39)