Structure of PDB 6xa1 Chain Ll Binding Site BS02

Receptor Information

>6xa1 Chain Ll (length=50) Species: 9606 (Homo sapiens)

SSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL

Ligand information

>6xa1 Chain L8 (length=155)

gacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcu
agcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuuc
gaacgcacuugcggccccggguuccucccggggcuacgccugucugagcg
ucgcu

........................................<<<<<<.<<.
....>>>.....(.<<<......>>.............>>>..)...>>>
....<<....>><<<<<<<<<.....>>>>>>>>>...............
.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xa1 Selective inhibition of human translation termination by a drug-like compound.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): R8 K15 K18 Q19 R21 I23 W26 I27 M29 K30 T31 K40
• Binding residue (residue number reindexed from 1): R7 K14 K17 Q18 R20 I22 W25 I26 M28 K29 T30 K39

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0002227 innate immune response in mucosa
• GO:0006412 translation
• GO:0019731 antibacterial humoral response
• GO:0050830 defense response to Gram-positive bacterium
• GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide

Cellular Component

• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xa1, PDBe:6xa1, PDBj:6xa1
• PDBsum: 6xa1
• PubMed: 33009412
• UniProt: P62891|RL39_HUMAN Large ribosomal subunit protein eL39 (Gene Name=RPL39)