Structure of PDB 8ohd Chain Lj Binding Site BS02

Receptor Information

>8ohd Chain Lj (length=86) Species: 9606 (Homo sapiens)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

Ligand information

>8ohd Chain 8 (length=148)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacaugaucaucgacacuucga
acgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu

.........................................<<<<<<<<<
....>>>>.....<.<<<......>>..........>>>..>...>>>..
..<<....>><<<<<<<<<>>>>>>>>>....................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ohd UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): R20 R21 C22 T59 G60 G62 R63 M64 R65 H66 L67 Y71 R72 F74 H76 R79 E80 G81 T82 P84 K85 K87
• Binding residue (residue number reindexed from 1): R19 R20 C21 T58 G59 G61 R62 M63 R64 H65 L66 Y70 R71 F73 H75 R78 E79 G80 T81 P83 K84 K86

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding
• GO:0097371 MDM2/MDM4 family protein binding
• GO:1990948 ubiquitin ligase inhibitor activity

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:1901798 positive regulation of signal transduction by p53 class mediator

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ohd, PDBe:8ohd, PDBj:8ohd
• PDBsum: 8ohd
• PubMed: 38383785
• UniProt: P61927|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)