Structure of PDB 8rxh Chain Lh Binding Site BS02

Receptor Information

>8rxh Chain Lh (length=127) Species: 347515 (Leishmania major strain Friedlin)

SCPRVQYRRRMHYATRGNRMKMVRTPGNKLVMQKRAKRSQGIHTPWVLGH
KRLGGTKALRHIDARLASRHEKSVSRAYGGVLSHDQVRDRVVRAFLVEEQ
RIVKQALKEHSKMKLSHKRTANKKKSK

Ligand information

>8rxh Chain L2 (length=1155)

cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacuca
gaacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugu
gaugcauccaagugguguauaucgcaaacugauuucugcccagugcucug
aaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaa
cuaugacucucuuaagguagccaaaugccucgucuuccaauuagagacgc
gcaugaauggauuaaugagauucccucugucccgaguuacuaucuagcga
aacgacagucaagggaacggacuugaagggcuaagcggggaaagaagacc
cuguugaguuugacuccagucuggcucugugcggcgacaucugaggcucg
gaacguugcuucacuuaucgaaugaagagaccaauggguuuagcguaguc
uucgggcuaugcaccgucuagguuugggaguccccuguggguacccaacc
gugcuguaaacugaaccaacgggauugcaguuccggagucuuguuucgag
acaucugccagauggggaguuuggcuggggcggcauaucuguuacacgac
aacgcagguguccuaaggcgagcucagugggaacagaaaucucacguaga
acacaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgaga
cugcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaaca
aaucauaccagaggugucagaauaauuaccacagggauaacuggcuugug
gcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcu
cuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguucaccca
cugacagggaacgugagcuggguuuagaccgucgugagacagguugguuu
uacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcgg
acgucgggucguugggccuggcgagcgguggguaguacaugguacgcuca
ucacc

........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>
>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<
....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<..
..<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<.......>>>>>..
...>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>....
........<<<<<........>>>>>..<<<<<<<..<<<.<<......<
<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>
>>..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<
....>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>
...................<<<<<......>>>>>..>>>>...>>>>>.
......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<........
...>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....
<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>
.<<<....>>>.>>.........<<<<<..............<<<<....
...>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<
<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.
<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>
>..>>>.>>>>>>>.......................<<<<.....>>>>
.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>
>>.>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
• Resolution: 2.93 Å
• Binding residue (original residue number in PDB): S2 C3 R5 V6 Y8 R11 Y14 R91 R94 V98 R102 K105 M114 H118 R120 K124
• Binding residue (residue number reindexed from 1): S1 C2 R4 V5 Y7 R10 Y13 R90 R93 V97 R101 K104 M113 H117 R119 K123

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
• PDBsum: 8rxh
• PubMed: 38722744
• UniProt: Q4QDP9