Structure of PDB 5lks Chain Lh Binding Site BS02

Receptor Information
>5lks Chain Lh (length=122) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVR
KSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEEN
LKTKKQQRKERLYPLRKYAVKA
Ligand information
>5lks Chain L8 (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcu
.........................................<<<<<<.<<
.....>>>.....(.<<<......>>.............>>>..)...>>
>....<<<..>>><<<<<<<<.......>>>>>>>>..............
......
Receptor-Ligand Complex Structure
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PDB5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		A2 K5 A6 R10 K35 S45 R48 R51 K52 A55 L58 T59 N62 Q63 K66 L81 R84 T88 R89 R92
Binding residue
(residue number reindexed from 1)		A1 K4 A5 R9 K34 S44 R47 R50 K51 A54 L57 T58 N61 Q62 K65 L80 R83 T87 R88 R91
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lks, PDBe:5lks, PDBj:5lks
PDBsum5lks
PubMed27665925
UniProtP42766|RL35_HUMAN Large ribosomal subunit protein uL29 (Gene Name=RPL35)

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