Structure of PDB 8rxx Chain Le Binding Site BS02

Receptor Information
>8rxx Chain Le (length=186) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRAGMKGKVLGKEKKAAIIDARKKAAESRKNRDDKRWKRVLANMDEEKRK
KFHGVGNTAKNSRVRGATRASLLKRTGRKPDAVSMEATIHLSKLLKKKTF
SKRAPLAIKRIKAFVGRLMKTKDNRIDASLNTYIWHKGVKGVPGRVRVLI
QRKSETTEGNKHKHFYTVISNVPVASFKGLTTKTVE
Ligand information
>8rxx Chain L2 (length=1149) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacuca
gaacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugu
gaugcauccaagugguguauaucgcaaacugauuucugcccagugcucug
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgacaucugaggcucggaa
cguugcuucacuuaucgaaugaagagaccaauggguuuagcguagucuuc
gggcuaugcaccgucuagguuugggaguccccuguggguacccaaccgug
cuguaaacugaaccaacgggaucaguuccggagucuuguuucgagacacu
gccagauggggaguuuggcuggggcggcauaucuguuacacgacaacgca
gguguccuaaggcgagcucagugggaacagaaaucucacguagaacacaa
gcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacugcga
aagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaaucau
accagaggugucagaauaauuaccacagggauaacuggcuuguggcggcc
aagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccu
aaccuagcgccgcagaagacgcuaaggguuggauuguucacccacugaca
gggaacgugagcuggguuuagaccgucgugagacagguugguuuuacccu
acuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucg
ggucguugggccuggcgagcgguggguaguacaugguacgcucaucacc
........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>
>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<
....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<..
<<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>>>.
.>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<...
.>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>...
................<<<<<....>>>>>..>>>>...>>>>>......
>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>
>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<....
..>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<..
..>>>.>>........<<<<<<..............<<<<.......>>>
>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<.
..<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<
..<<<<<<<.<......>.>>>>>..>>.<<<.........>>>.....>
>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>
.>>>>>>>.......................<<<<.....>>>>.<<<<<
<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		R30 K31 R33 D34 D35 R37 W38 R40 N44 K52 F53 V56 R66 G67 K98 K103 K110
Binding residue
(residue number reindexed from 1)		R29 K30 R32 D33 D34 R36 W37 R39 N43 K51 F52 V55 R65 G66 K97 K102 K109
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtE9AFF2

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