Structure of PDB 8rxh Chain Lc Binding Site BS02

Receptor Information
>8rxh Chain Lc (length=229) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRAAFKQQQTESFKKAVVARKAAKAALKKTAYLRARKYSREYRGAEKKLV
TLRRQAASHGNYYLEAKPKVAVVTRIRGIAKVNPKQRKILQLLRLRQIFN
TVFVKMNKPMENMLRAVEPYIAYGYPSLATVRAMVYKRGYLKINGQRVKI
TDNQMIKDKYNNVDIVCAEDMVNQIYTCGKHFRTVTHGMWPFKLAPPAGG
MRQKRRHFVEGGDYGNRDTLINRFLARMI
Ligand information
>8rxh Chain L8 (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaa
guuaagcacucacaggcucaguuaguacugaggucagugaugacucggga
acccugagugccguacuccu
<<<<<<<......<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>..
...>>>>>>..>>>>>>>..
Receptor-Ligand Complex Structure
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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		R138 E141 P142 R228 R229 H230 V232 E233
Binding residue
(residue number reindexed from 1)		R115 E118 P119 R205 R206 H207 V209 E210
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4Q9H4

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