Structure of PDB 8rxx Chain LY Binding Site BS02

Receptor Information

>8rxx Chain LY (length=133) Species: 347515 (Leishmania major strain Friedlin)

TKFLKPGKVVIVTAGRYAGHKAVIVQNSDVVTKERPYGRALLAGIKKYPK
KVVRGMSKQTIARRSQVGVFLRVVNHKHFLPTRYNVDMSKELRGKINVSD
ASKRSRSKRLVRHVFQARYNAGSSMWFFQRLRF

Ligand information

>8rxx Chain L3 (length=183)

agugguaaugcgaaacacuugccagguaacaaaucaauccucccacggug
agcuuucuuuucaccauaauccaccuugggccuuuuuacuuucgcguugu
ucggagcgggggcucaagauugaaaaaugcagcucuuacugucauuugug
aguucugcgcauuaaagcaaaaaccuggggugu

.<<......>>.....<<<..<<<<<<.......<<...<<<....<<<<
<<.......>>>>>><...<<.<.<<<<<<<<<<<.......<<......
.>>....>>>>>>>>>>>.>.>>....><..<..........>..>...>
>>...>>...............>>>>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
• Resolution: 2.97 Å
• Binding residue (original residue number in PDB): G16 R17 R36 Y38 K47 K48 K51 R64 R65 R73 V74 N76 K78 H79 R131 R133
• Binding residue (residue number reindexed from 1): G15 R16 R35 Y37 K46 K47 K50 R63 R64 R72 V73 N75 K77 H78 R130 R132

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
• PDBsum: 8rxx
• PubMed: 38722744
• UniProt: Q4Q504