Structure of PDB 7f5s Chain LX Binding Site BS02

Receptor Information
>7f5s Chain LX (length=119) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAM
KKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAY
VRLAPDYDALDVANKIGII
Ligand information
>7f5s Chain L8 (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcu
.........................................<<<<<<<<<
....>>>>.....<.<<<......>>.............>>>..>...>>
>....<<....>><<<<<<<<<.....>>>>>>>>>..............
......
Receptor-Ligand Complex Structure
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PDB7f5s METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		P49 T51 L52 R55 R56 K63 P66 R67 R68 K70 K103 H107 Q108
Binding residue
(residue number reindexed from 1)		P12 T14 L15 R18 R19 K26 P29 R30 R31 K33 K66 H70 Q71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0045296 cadherin binding
GO:1904841 TORC2 complex binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f5s, PDBe:7f5s, PDBj:7f5s
PDBsum7f5s
PubMed35674491
UniProtP62750|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)

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