Structure of PDB 6y6x Chain LX Binding Site BS02

Receptor Information
>6y6x Chain LX (length=120) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESA
MKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKA
YVRLAPDYDALDVANKIGII
Ligand information
>6y6x Chain L8 (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcu
.........................................<<<<<<<<<
....>>>>.....<.<<<......>>.............>>>..>...>>
>....<<....>><<<<<<<<<.....>>>>>>>>>..............
......
Receptor-Ligand Complex Structure
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PDB6y6x Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		P49 T51 L52 R55 R56 K63 R67 N69 K70 K103 Q108
Binding residue
(residue number reindexed from 1)		P13 T15 L16 R19 R20 K27 R31 N33 K34 K67 Q72
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6y6x, PDBe:6y6x, PDBj:6y6x
PDBsum6y6x
PubMed32601485
UniProtP62750|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)

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