Structure of PDB 7n2v Chain LV Binding Site BS02

Receptor Information
>7n2v Chain LV (length=110) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKV
LESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRT
SHITVVVSDR
Ligand information
Ligand IDSCM
InChIInChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,12-,13+,14+/m1/s1
InChIKeyUNFWWIHTNXNPBV-WXKVUWSESA-N
SMILES
SoftwareSMILES
CACTVS 3.341CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O
OpenEye OEToolkits 1.5.0CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O
OpenEye OEToolkits 1.5.0C[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H]([C@H]3O2)NC)O)NC)O)O
CACTVS 3.341CN[CH]1[CH](O)[CH](NC)[CH]2O[C]3(O)[CH](O[CH](C)CC3=O)O[CH]2[CH]1O
ACDLabs 10.04O=C1C2(OC3C(NC)C(O)C(NC)C(O)C3OC2OC(C1)C)O
FormulaC14 H24 N2 O7
NameSPECTINOMYCIN;
ACTINOSPECTACIN;
ESPECTINOMICINA;
CHX-3101
ChEMBLCHEMBL1167
DrugBankDB00919
ZINCZINC000053006806
PDB chain7n2v Chain 23 Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7n2v Structural basis of early translocation events on the ribosome.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		V45 E52
Binding residue
(residue number reindexed from 1)		V45 E52
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042255 ribosome assembly
GO:0042256 cytosolic ribosome assembly
GO:0046677 response to antibiotic
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7n2v, PDBe:7n2v, PDBj:7n2v
PDBsum7n2v
PubMed34234344
UniProtP61175|RL22_ECOLI Large ribosomal subunit protein uL22 (Gene Name=rplV)

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