Structure of PDB 8xt0 Chain LR Binding Site BS02

Receptor Information
>8xt0 Chain LR (length=146) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVI
RTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQ
RCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE
Ligand information
>8xt0 Chain L2 (length=56) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaguguagcuuaaaagcacccaacuuacacuuaggagauucaauugacg
cucuga
<<<<<...<<<....>>>.<<.<<.......>>.>>....<<<..>>>.>
>>>>..
Receptor-Ligand Complex Structure
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PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		T85 Q86 H87 H88 R107 N120 V121 W150 S154 S156
Binding residue
(residue number reindexed from 1)		T52 Q53 H54 H55 R74 N87 V88 W117 S121 S123
Gene Ontology
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtA8K9D2

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