Structure of PDB 8rxx Chain LO Binding Site BS02

Receptor Information
>8rxx Chain LO (length=290) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVKVVKNKAYFKRFQVKYRRRREGKTDYHARRQMVLQDKTKFGSPKYRLV
VRITNKDIIAQIVQAKIVGDEVVMAAYAHELPAFGIEHGLTNYAAAYATG
LLLARRTLAKLGIADKFQGAKEADGSYSAVRTKKDDDEERFPFKAILDVG
LARTTTGARVFGVLKGAVDGGMAVPHRPNRFPGYNKEKSSLDAKVHRDRI
FGKHVADYLKQVKEEASSNPDEKCVQFSKYMAAKVLPESIEGMYKKAHAA
IRADPSKSLPKHKSYKTKKLSGAEKRAAAKAKVAAIRERL
Ligand information
>8rxx Chain L2 (length=1149) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacuca
gaacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugu
gaugcauccaagugguguauaucgcaaacugauuucugcccagugcucug
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgacaucugaggcucggaa
cguugcuucacuuaucgaaugaagagaccaauggguuuagcguagucuuc
gggcuaugcaccgucuagguuugggaguccccuguggguacccaaccgug
cuguaaacugaaccaacgggaucaguuccggagucuuguuucgagacacu
gccagauggggaguuuggcuggggcggcauaucuguuacacgacaacgca
gguguccuaaggcgagcucagugggaacagaaaucucacguagaacacaa
gcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacugcga
aagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaaucau
accagaggugucagaauaauuaccacagggauaacuggcuuguggcggcc
aagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccu
aaccuagcgccgcagaagacgcuaaggguuggauuguucacccacugaca
gggaacgugagcuggguuuagaccgucgugagacagguugguuuuacccu
acuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucg
ggucguugggccuggcgagcgguggguaguacaugguacgcucaucacc
........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>
>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<
....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<..
<<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>>>.
.>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<...
.>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>...
................<<<<<....>>>>>..>>>>...>>>>>......
>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>
>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<....
..>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<..
..>>>.>>........<<<<<<..............<<<<.......>>>
>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<.
..<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<
..<<<<<<<.<......>.>>>>>..>>.<<<.........>>>.....>
>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>
.>>>>>>>.......................<<<<.....>>>>.<<<<<
<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>.
Receptor-Ligand Complex Structure
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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		V4 K8 Y12 F16 Q17 K19 R23 T28 D29 Q35 M36 K48 L156 T159 F166 P180 H181 R182 R185
Binding residue
(residue number reindexed from 1)		V2 K6 Y10 F14 Q15 K17 R21 T26 D27 Q33 M34 K46 L151 T154 F161 P175 H176 R177 R180
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtE9AF09

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