Structure of PDB 7xny Chain LJ Binding Site BS02

Receptor Information
>7xny Chain LJ (length=169) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRS
FGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGI
QEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISK
EEAMRWFQQKYDGIILPGK
Ligand information
>7xny Chain L2 (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcuu
<<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB7xny A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		N10 M12 R13 Q46 T47 V49 T73 R75 G138 I141 R147 C150 I151 A153 K154 H155 R156
Binding residue
(residue number reindexed from 1)		N1 M3 R4 Q37 T38 V40 T64 R66 G129 I132 R138 C141 I142 A144 K145 H146 R147
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
GO:0031625 ubiquitin protein ligase binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006605 protein targeting
GO:0010628 positive regulation of gene expression
GO:0032092 positive regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0042273 ribosomal large subunit biogenesis
GO:0050821 protein stabilization
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435 negative regulation of protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xny, PDBe:7xny, PDBj:7xny
PDBsum7xny
PubMed36259929
UniProtP62913|RL11_HUMAN Large ribosomal subunit protein uL5 (Gene Name=RPL11)

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