Structure of PDB 7mq9 Chain LJ Binding Site BS02

Receptor Information

>7mq9 Chain LJ (length=469) Species: 9606 (Homo sapiens)

AGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPP
YNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSED
GGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI
PNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVL
SVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTV
TCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHED
ETIVVGMTNGILSVKHRNYMKQRDDILINRPAKKHLELYDRDLKHFRISK
ALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVLNFL
IRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEID
YQRELLETLGMMDMLFATM

Ligand information

>7mq9 Chain L1 (length=1301)

accugguugauccugccaguagcauaugcuugucucaaaaagccaugucu
aaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucagu
uaugguuccuuuggucgcucgcuccuuacuuggauaacugugguaauucu
agagcuaauacaugccgacgggcgcugacccccggggggaugcgugcauu
uaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggc
uagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauu
cgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccaugg
ugaccacgggugagggaaucaggguucgauuccggagagggagccugaga
aacggcuaccacauccaaggaaggaggcgcgcaaauuacccacucccgac
ccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccu
guaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagg
gcaagucuggugccagcagccgcgguagcuccaauagcguauauuaaaag
cucguaguuggaucauuaagagggacggccgggggcauucguauugcgcc
gcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagca
uuugccaagaauguuuucauuaaucaagaacgaaccgaccggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccagaguaug
guugugaaacuuaaaggaauugacggaagggcaccaccaggaguggagcc
ugcggcacccggcccggacacggacaggauugacagauugauagcucuuu
cucgauuccguggguuggugcauggccguucguugguggagcgauuuggu
uaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcgu
ucagccacccgagauugagcaauaacaggucugugaugcccguccgggcg
cgcgcuacacugacuggcucagcguguaaccccauucguaggaauuccca
guaagugcgggucauaagcuugcguugauuaagucccugcccuuuacaca
ccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucgg
ccccgccggggucggcccacggcccuggcggagcgcugagaagacggucg
aacuugacuaucuagaggaaguaaaagguuuccguaggugaaccugcgga
a

....................<<.<<<<<<...<.<<.....<<<..<<..
..<<....<<..........>>...>>.>>........<.......<<<.
<....<<....<<<................<<.....<<.<<.......>
>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<
<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>....
..>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>..
.>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>
>......>>>....<<<<<<.......>>>>>>...>.<<.<<<<.....
...>>>>.>>.<.<<<..>>>.>..>>>........<<<<....<<<...
..>>>..>>>>.....>>.>.....<<<<<<<<<.<<<....>>>.>.>>
>>.>>>>......<<..<...........>..>>.........<<<<<<.
......<<<....>>>............>>>>>>..>>>>>>.>>....<
.<<...<<<.<<<.>>>....<<<<<<..<...<<<<..<<<.<<<<<<<
<...<<<......>>>......>>>>>>>>.>>>.......<<....>>.
..>>>>..>..>>>.>>>...>>>...>>.>...<<<...<<<..<.<<<
<<<.<<<........>>>>>>>>>.>..>>>..>>>..............
.....................<<<<<<<<<<<<..<<..<<<<<..<<<.
<<<<...<<<<<......<<<<<<.......<<.<<<........>>>.>
>.....>>>>>>....<<<<<<<<<<<<<<.<<<.<<.<<....>><<<.
.....>>>...>>.>>>....<<<...<...<..>..>.....<<<<<..
...>>>>>........>>>....>>>.>>.>>>>>.>>>>...>>>>>>>
>>.>>>.....<<.<<<..............>>>.>>......>>>>>..
...<<<<<<<.........>>>>>>>......>>...>>>>>>>......
....>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<
<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>.
.>>>.>>>>>>>>.>.>>.>>>>......<<<<<<<<<....>>>>>>>>
>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mq9 Nucleolar maturation of the human small subunit processome.
• Resolution: 3.87 Å
• Binding residue (original residue number in PDB): R78 R112
• Binding residue (residue number reindexed from 1): R77 R111

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis
• GO:0045943 positive regulation of transcription by RNA polymerase I
• GO:2000234 positive regulation of rRNA processing

Cellular Component

• GO:0001650 fibrillar center
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:7mq9, PDBe:7mq9, PDBj:7mq9
• PDBsum: 7mq9
• PubMed: 34516797
• UniProt: Q8TED0|UTP15_HUMAN U3 small nucleolar RNA-associated protein 15 homolog (Gene Name=UTP15)