Structure of PDB 8pv4 Chain LG Binding Site BS02

Receptor Information

>8pv4 Chain LG (length=235) Species: 759272 (Thermochaetoides thermophila DSM 1495)

PKNPLLEKRPRNFGIGQDIQPKRNLSRMVKWPEYIRLQRQKKILRMRLKV
PPAIAQFQYTLDKNLAAQAFKLLNKYRPETKQEKKERLLREATAIKEGKK
KEDVSKKPYTVKYGLNHVVGLIENKKASLVLIANDVDPIELVVFLPALCR
KMGIPYAIIKGKARLGTLVHKKTAAVVAITEVRSEDKNELAKLISAVKEG
YLEKVEDTRKRWGGGIMGFKAQKREEKRKKSLETA

Ligand information

>8pv4 Chain C2 (length=156)

aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagc
gaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucu
uugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgag
cgucau

.........................................<<<<<<<<<
....>>>>.....<.<<<......>>..............>>>..>...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8pv4 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): Y58 I59 Q62 R63 K66 K87 D159 K184 R188
• Binding residue (residue number reindexed from 1): Y34 I35 Q38 R39 K42 K63 D135 K160 R164

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8pv4, PDBe:8pv4, PDBj:8pv4
• PDBsum: 8pv4
• PubMed: 37921038
• UniProt: G0SAJ9