Structure of PDB 8oo0 Chain LG Binding Site BS02

Receptor Information

>8oo0 Chain LG (length=235) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KAPKNPLLEKRPRNFGIGQDIQPKRNLSRMVKWPEYIRLQRQKKILRMRL
KVPPAIAQFQYTLDKNLAAQAFKLLNKYRPETKQEKKERLLREATAIKEG
KKKEDVSKKPYTVKYGLNHVVGLIENKKASLVLIANDVDPIELVVFLPAL
CRKMGIPYAIIKGKARLGTLVHKKTAAVVAITEVRSEDKNELAKLISAVK
EGYLEKVEDTRKRWGGGIMGFKAQKREEKRKKSLE

Ligand information

>8oo0 Chain 4 (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagc
gaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucu
uugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgag
cgucau

.........................................<<<<<<.<<
.....>>>.....(.<<<......>>..............>>>..)...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
......

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8oo0 Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Resolution	3.1 Å
Binding residue (original residue number in PDB)	Y58 I59 Q62 R63 K184
Binding residue (residue number reindexed from 1)	Y36 I37 Q40 R41 K162

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

	Biological Process
GO:0000470	maturation of LSU-rRNA
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:8oo0, PDBe:8oo0, PDBj:8oo0
PDBsum	8oo0
PubMed	38267453
UniProt	G0SAJ9

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