Structure of PDB 8ia0 Chain LG Binding Site BS02

Receptor Information

>8ia0 Chain LG (length=205) Species: 759272 (Thermochaetoides thermophila DSM 1495)

MVKWPEYIRLQRQKKILRMRLKVPPAIAQFQYTLDKNLAAQAFKLLNKYR
PETKQEKKERLLREATAIKEVSKKPYTVKYGLNHVVGLIENKKASLVLIA
NDVDPIELVVFLPALCRKMGIPYAIIKGKARLGTLVHKKTAAVVAITEVR
SEDKNELAKLISAVKEGYLEKVEDTRKRWGGGIMGFKAQKREEKRKKSLE
TAIKV

Ligand information

>8ia0 Chain C2 (length=256)

aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagc
gaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucu
uugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgag
cgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugc
ucgcgggcccugaaaagcaguggcgggcucgcuggcgggugccagccgua
aaaccc

.........................................<<<<<<<<<
....>>>>.....<.<<<......>>..............>>>..>...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
...............<<<<<<...>>>>>>....<<<<.<<<<<<<....
>>>>>>>>>>>..........<<<<<<<<<<<..>>>>>>.>>.>>>...
......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ia0 Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Y58 I59 Q62 R63 K66 R69 K87 N88 Q92 K184 R188 S219
• Binding residue (residue number reindexed from 1): Y7 I8 Q11 R12 K15 R18 K36 N37 Q41 K127 R131 S162

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ia0, PDBe:8ia0, PDBj:8ia0
• PDBsum: 8ia0
• PubMed: 37129998
• UniProt: G0SAJ9