Structure of PDB 8i9r Chain LG Binding Site BS02

Receptor Information

>8i9r Chain LG (length=183) Species: 759272 (Thermochaetoides thermophila DSM 1495)

MVKWPEYIRLQRQKKILRMRLKVPPAIAQFQYTLDKNLAAQAFKLLNKYR
PETKQEKKERLLREATAIKEVSKKPYTVKYGLNHVVGLIENKKASLVLIA
NDVDPIELVVFLPALCRKMGIPYAIIKGKARLGTLVHKKTAAVVAITEVR
SEDKNELAKLISAVKEGYLEKVEDTRKRWGGGI

Ligand information

>8i9r Chain C2 (length=228)

aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagc
gaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucu
uugaacgcagcgcccgccgguauuccggcgggcaugccuguucgagcguc
auuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgc
gggcccugaaaagcaguggcgggcucgc

.........................................<<<<<<.<<
.....>>>.....(.<<<(.....>>............).>>>..)...>
>>....<<.>><<<<<<<<<....>>>>>>>>>.................
...........<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>
>>>>>>>.....................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8i9r Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): Y58 I59 Q62 R63 K66 K87 Q92 A215 S219
• Binding residue (residue number reindexed from 1): Y7 I8 Q11 R12 K15 K36 Q41 A158 S162

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8i9r, PDBe:8i9r, PDBj:8i9r
• PDBsum: 8i9r
• PubMed: 37129998
• UniProt: G0SAJ9