Structure of PDB 7nrd Chain LG Binding Site BS02

Receptor Information
>7nrd Chain LG (length=294) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRLVV
RFTNKDIICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGL
LIARRTLQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRT
TTGARVFGALKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFGGH
VSQYMEELADDDEERFSELFKGYLADDIDADSLEDIYTSAHEAIRADPAF
KPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ
Ligand information
>7nrd Chain LB (length=121) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacugu
aguuaagcugguaagagccugaccgaguaguguagugggugaccauacgc
gaaacucaggugcugcaaucu
Receptor-Ligand Complex Structure
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PDB7nrd Structure of Gcn1 bound to stalled and colliding 80S ribosomes.
Resolution4.36 Å
Binding residue
(original residue number in PDB)		K8 S10 S13 S14 T18 F20 R21 R22 R24 E25 K27 T28 Y30 R33 V52 R54 T56 N57 K58 Q63 I65 I69 T70 G71 D72 V73 V74 H90 G91 T93 N94 W95 Q151 R152 T154 T155 R158 H203 Y207 E221 F223 T256 K258 K259 F260 K262 Q264 Y265 A266 E268 S269 K270 Y272 R273 Q274 T275 K276 L277 R282 K289
Binding residue
(residue number reindexed from 1)		K5 S7 S10 S11 T15 F17 R18 R19 R21 E22 K24 T25 Y27 R30 V49 R51 T53 N54 K55 Q60 I62 I66 T67 G68 D69 V70 V71 H87 G88 T90 N91 W92 Q148 R149 T151 T152 R155 H200 Y204 E218 F220 T253 K255 K256 F257 K259 Q261 Y262 A263 E265 S266 K267 Y269 R270 Q271 T272 K273 L274 R279 K286
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nrd, PDBe:7nrd, PDBj:7nrd
PDBsum7nrd
PubMed33790014
UniProtP26321|RL5_YEAST Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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