Structure of PDB 8g5y Chain LC Binding Site BS02 |
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| >8g5y Chain L5 (length=3721)
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cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgc
ggcggaucuuucccggcgggggaccgucccccgaccggcgaccggccgcc
gccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacgg
cugggaaggcccggcggggaagguggcucgggggcccccgaguguuacag
cccccccggcagcagcacucgccgaaucccggggccgagggagcgagacc
cgucgccgcgcucuccccccugggggggccgggccaccccucccacggcg
cgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccg
ucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggag
cgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuug
aaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacga
aagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgag
gugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgu
cucgcccgccgcgccggggagguggagcacgagcgcacguguuaggaccc
gaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugg
uggagguccguagcgguccugacgugcaaaucggucguccgaccugggua
uaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaagu
uucccucaggauagcuggcgcucucgcagacccgacgccacgcaguuuua
uccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccu
auucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccg
ggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggc
gcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcuca
ucagaccccagaaaagguguugguugauauagacagcaggacgguggcca
uggaagucggaauccgcuaaggaguguguaacaacucaccugccgaauca
acuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccg
ucgccggcagucgagaguggacgggagcggcgggcccgcggacgcuacgc
cgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgg
gcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauau
ucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacag
caguugaacaugggucagucgguccugagagaugggcgagcgccguuccg
aagggacgggcgauggccuccguugcccucggccgaucgaaagggagucg
gguucagauccccgaauccggagcggagaugggcgccgcgaggcguccag
ugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagag
uucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccga
gagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggug
agcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgc
cgggccguacccauauccgcagcaggucuccaaggugaacagccucuggc
auguuggaacaauguagguaagggaagucggcaagccggauccguaacuu
cgggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggu
gcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggc
ccgcggcggguguugacgcgaugugauuucugcccagugcucugaauguc
aaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuauga
cucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcauga
auggaugaacgagauucccacugucccuaccuacuauccagcgaaaccac
agccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguug
agcuugacucuagucuggcacggugaagagacaugagagguguagaauaa
gugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcg
ggguccgccggcccugcgggccgccggugaaauaccacuacucugaucgu
uuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgc
uucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccg
gggacagugccagguggggaguuugacuggggcgguacaccugucaaacg
guaacgcagguguccuaaggcgagcucagggaggacagaaaccucccgug
gagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacag
accgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagca
ggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaag
cguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuauc
auugugaagcagaauucaccaagcguuggauuguucacccacuaauaggg
aacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacu
gaugauguguuguugccaugguaauccugcucaguacgagaggaaccgca
gguucagacauuugguguaugugcuuggcugaggagccaauggggcgaag
cuaccaucugugggauuaugacugaacgccucuaagucagaaucccgccc
aggcggaacgauacggcagcgccgcggagccucgguuggccucggauagc
cggucccccgcgggguccggugcggagugcccuucguccugggaaacggg
gcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguuc
guggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgg
gguuucguacguagcagagcagcucccucgcugcgaucuauugaaaguca
gcccucgacacaaggguuugu |
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>...<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>
>>>>.....<<<<<..((((((>>>>>..>>>..................
................<<....>>...............<<<<....>>>
>..................................<<<<<<<<..<<<.<
<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<<...
<<<<<.<<<..<<<...>>>>>>>>>>>..>>>..>>>>...>>>>>>>>
>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<
<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......
>>>>.>.>>>........>>>>>>..>>>>>>>>>>>.............
.......<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<
<<<<<<<.<<<<<<<.<<<<....>>>>.>>>>>>>.>>>.>>>>>>>>>
>.>>>...>>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>...
.>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<....
....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.......
.>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<
<<<<...<<<..<<<..((((.(((.>>>..>>>....>>>>>.<<<<<<
<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.
<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>
>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>
>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<
.<<<....>>>.><<.<<<<<<<..................<<<.<<<<<
<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>
.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>
>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>
....<<<......>>>...<<<<<<<...<<<(((.......<<<<<...
..<<..........<<<.<<<<<<<<<<........<<<<.<<....<<.
........>>....>>.........<<......>>...>>>>....>>>>
>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<
<<<<.<<<...........))).)))).....................>>
>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....
>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<
<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.
....>>.>>>>>>....((<<<<<<...<<....<<<....>>>......
....<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<
<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>.
.<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<
..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>..
...>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>..
.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>
>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>
....<<<<.....<<<<<<<.<<...............<<<<<.......
........>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>...
.........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<
<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.
....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<.......>>>>>.....>..
...>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>..
..<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<
<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........
<..<<.............................................
..................................>>..>.>>>>.>>.>>
>>>>>>>>...<<<<<.....<<<<..<<.<<............>>>>..
............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>
>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<......
.....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>...
..<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>
><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>
>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<
<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<
.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>
>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>
>>>.....<<<<<<.<..<<<....<<<<<.................>>>
>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>
>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>
>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<
<<<.<<<<...>>>>.>>>>>.......>>>...<<<..<<<<....<<<
<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>............
..>>>>..>>>>>>>>><<<<<....................<<.<<<<<
<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>...
.>>>>.>>>.>>..>>>>>.. |
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| PDB | 8g5y mRNA decoding in human is kinetically and structurally distinct from bacteria. |
| Resolution | 2.29 Å |
Binding residue
(original residue number in PDB) | A4 R33 I36 N38 F39 H41 T42 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 Q61 T62 S63 T69 G70 A72 V73 A74 R75 I76 P77 R80 G82 G83 T84 H85 R86 Q89 G90 N94 M95 C96 R97 G98 R100 M101 F102 A103 P104 K106 W108 R109 R110 R114 N116 T117 T118 Q119 K120 R121 K140 R143 K163 T164 K165 K172 K173 K175 N178 K181 K182 Y184 R188 R190 A191 G192 K193 K195 R197 R199 R201 R204 R205 K219 R222 N223 K234 L235 N236 K239 P242 G243 H245 R268 K274 S275 R291 L293 R303 A304 P305 R306 K307 K308 I309 H310 R311 R312 L314 K316 N317 K320 N321 L322 R323 K327 K333 R336 T339 R342 Q343 N346 H347 R350 K353 |
Binding residue
(residue number reindexed from 1) | A2 R31 I34 N36 F37 H39 T40 R43 K44 N45 N46 R47 Q48 Y50 V52 S53 A56 H58 Q59 T60 S61 T67 G68 A70 V71 A72 R73 I74 P75 R78 G80 G81 T82 H83 R84 Q87 G88 N92 M93 C94 R95 G96 R98 M99 F100 A101 P102 K104 W106 R107 R108 R112 N114 T115 T116 Q117 K118 R119 K138 R141 K161 T162 K163 K170 K171 K173 N176 K179 K180 Y182 R186 R188 A189 G190 K191 K193 R195 R197 R199 R202 R203 K217 R220 N221 K232 L233 N234 K237 P240 G241 H243 R266 K272 S273 R289 L291 R301 A302 P303 R304 K305 K306 I307 H308 R309 R310 L312 K314 N315 K318 N319 L320 R321 K325 K331 R334 T337 R340 Q341 N344 H345 R348 K351 |
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| Enzyme Commision number |
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