Structure of PDB 8xt2 Chain LB Binding Site BS02

Receptor Information

>8xt2 Chain LB (length=237) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ANFVSWKSRTKYTITPVKMRKSGGRDHTGRIRVHGIGGGHKQRYRMIDFL
RFRPEETKSGPFEEKVIQVRYDPCRSADIALVAGGSRKRWIIATENMQAG
DTILNSNHIGRMAVAAREGDAHPLGALPVGTLINNVESEPGRGAQYIRAA
GTCGVLLRKVNGTAIIQLPSKRQMQVLETCVATVGRVSNVDHNKRVIGKA
GRNRWLGKRPNSGRWHRKGGWAGRKIRPLPPMKSYVK

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8xt2 Chain LB Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	Y131 D132 R135
Binding residue (residue number reindexed from 1)	Y71 D72 R75
Annotation score	4

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0032543	mitochondrial translation

	Cellular Component
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005762	mitochondrial large ribosomal subunit
GO:0005840	ribosome
GO:1990904	ribonucleoprotein complex

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Cellular Component

External links

PDB	RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum	8xt2
PubMed	38942792
UniProt	Q5T653\|RM02_HUMAN Large ribosomal subunit protein uL2m (Gene Name=MRPL2)

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