Structure of PDB 6b4v Chain LB Binding Site BS02

Receptor Information

>6b4v Chain LB (length=181) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PLDLALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

Ligand information

>6b4v Chain GB (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga

<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>..
.....>>>.>>>>>>>>>>>

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6b4v Mechanism of Inhibition of Translation Termination by Blasticidin S.
Resolution	3.4 Å
Binding residue (original residue number in PDB)	P2 N27 W29 E30 Q66 K67 A69 V70 T71 R91 V92 T93 R95 R96 R98
Binding residue (residue number reindexed from 1)	P1 N26 W28 E29 Q65 K66 A68 V69 T70 R90 V91 T92 R94 R95 R97

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:6b4v, PDBe:6b4v, PDBj:6b4v
PDBsum	6b4v
PubMed	29366636
UniProt	Q72I16\|RL5_THET2 Large ribosomal subunit protein uL5 (Gene Name=rplE)

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