Structure of PDB 8fkx Chain LA Binding Site BS02

Receptor Information

>8fkx Chain LA (length=138) Species: 9606 (Homo sapiens)

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMSSPCHIEMILTEKE

Ligand information

>8fkx Chain L3 (length=2250)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggagga
uucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcg
ccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcuc
gggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggg
gccgagggagcgccgcgcucuccggccgggccaggccacggagcgcacgg
ggucggcggcgacgucggcuacccacccgacccgucuugaaacacggacc
aaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccgug
gcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgucu
cgcccggggagguggagcacgagcgcacguguuaggacccgaaagauggu
gaacuaugccgguauaggggcgaaagacuaaccaucuaguagcugguucc
cuccgaaguuucccggauagcuggcgcucuccgcaguuuuauccgguggg
uaagaagcccggcucgagccgggcguggaaugcgagugccuagugggcca
cuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaa
ggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugaua
uagacagcaggacgguggccauggaagucggaauccgcuaaggagugugu
aacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggag
cgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacga
guaggagggccgcugcggugagccuugaagccuagggcgcgggcccgggu
ggagccgccgcaggugcagaucuuggugguaguagcauucaaacgagaac
uuugaaggccgaggggcgauggccuccggcccucgcggagagugaaucuc
gcuggcaauguagguaagggaagucgggaauccgauucccacugucccua
ccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucag
cggggagaagacccuguugagcuugacucuagucuggcacggugaagaga
caugagagguguagaauaagugggaggcggccgccggugaaauaccacua
cucugaucguuuuuuccagugccagguggggaguuauccuucugaccuuu
uggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcu
uguggcggccaagcgcgacgucgcuuuuugaugaugucggcucuuccuau
cauugugaagcagaauucaccaagcguuggauuguucacccacuaauagg
gaacgugagcuggggaccgucgugagacagguuagucccuacugaugguu
guugccaugguaauccugcucaguacgagaggaaccgcagguucagacau
uugguggugcuuggcugaggagccaauggggcgaagcuaccaucuguggg
auuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauaa
gcgccgcggagccucgguuggccucggauagccgguccccgggguccggu
gcggagugcccuucguccugggaaacggggcgcggccggagaggcggccg
cccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaac
cauucguagacgaccugcuucugggucgggguuucguacguagcagagca
gcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
...................<<<<<<<<..<<<.<<...<<<<<<<<.<<<
.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<
<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<
<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>
>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>....
..>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<
<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>
>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<
<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<
...<<<<<<..>>>>>><<.<....>.>>.>>>>>>......>.>>..<<
<<<<......<<<.>>>..<<.<<<<<<<...<<<.<<<<<<<<...>>>
>>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<
.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...
<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.
....<.<<<<<.<<....<<.........>>....>>.........<<..
....>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>
>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>.
...>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>
...>>>>>>>>>>..>.....>>>>>><<.....<<.<<<<<<.......
>>>>>>.<<<<..<<<<...........>>>>..<<<<<.......>>.>
>>>>>>...<<<<<<.<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>
>>>>>......>>....>>...<<<<<<........>>>>>>....<<<<
.<<<<......<<<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<
<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.
>>>>.>>.>>>>>>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.
........>>>>>>>>>>........>>>>>.>.>>>>>>..........
...<<<<<<...<..>...>>>>>>.......((...<<<<<<<<<<<..
<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>
>>....>>>>>>..<<<<<<<....>>>.>>>>...>>>>.>>>>..<<<
<<<.<..<<<..<.<<<<<.................>>>>>.><<<<...
.<<<<.<<.<<<<<<<....>>>>>..>>.>>...>>>>...>>>><<<<
<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<
<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>
.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>
>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<
<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<
<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkx Principles of human pre-60 S biogenesis.
• Resolution: 2.59 Å
• Binding residue (original residue number in PDB): R18 S20 H25 K27 R30 Q34 K37 K43 R62 Y63 G65 G66 R69 A71 K74 Q75 T79 R82 W83 K86 N97 S100 Q118 V119 S141
• Binding residue (residue number reindexed from 1): R17 S19 H24 K26 R29 Q33 K36 K42 R61 Y62 G64 G65 R68 A70 K73 Q74 T78 R81 W82 K85 N96 S99 Q117 V118 S125

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fkx, PDBe:8fkx, PDBj:8fkx
• PDBsum: 8fkx
• PubMed: 37410842
• UniProt: P18621|RL17_HUMAN Large ribosomal subunit protein uL22 (Gene Name=RPL17)