Structure of PDB 8fkq Chain L9 Binding Site BS02

Receptor Information
>8fkq Chain L9 (length=183) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRL
GYKAKQGYVIYRIRVRRGGQLKFARSLQSVAEERAGRHCGALRVLNSYWV
GEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKS
RGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR
Ligand information
>8fkq Chain L3 (length=1565) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgaccucagaucagacguggcgacccgcuggcauauuagucagcggagg
agaagaaacuaaccaggauucccucaguaacggcgagugaacagggaaga
gcccagcgccgaauccccgccccgggggcgcgggacauguggcguacgga
agacccgcuccccggcgccgcucguggggggcccaaguccuucugaucga
ggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgg
gcccgggucuucccggagucggguugcuugggaaugcagcccaaagcggg
ugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguac
cguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgug
aaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauuc
aacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
cccgaguguuacagcccccccggcagcagcacucgccgaaucccggggcc
gagggagcgccgcgcucuccggccgggccaggccacgcgagcgcacgggg
ucggcggcgacgucggcuacccacccgacccgucuacacggaccaaggag
ucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaa
ggugggaucccgaggccgccgagggcgcaccaccggccgcacgagcgcac
guguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccg
aaguuucccucaggauagcuggcgcucucgcaguuuuauccgguggguaa
gaagccggcguggaaugcgagugccuagugggccacuuuuagaacuggcg
cugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucgg
cgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgc
cgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgg
gcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguu
ggaacaauguaggaccuacuauccagcgaaaccucagcacugaugauguu
guugccaugguaauccugcucaguacgagaggaaccgcagguucagacau
uugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugu
gggcccgcccaggcggaacgauagcgccgcggagccucgguuggccucgg
auagccgguccccgggguccggugcggagugcccuucguccugggaaacg
gggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacgu
ucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucggg
guuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcc
cucgacacgguuugu
........................<<<<<<............>>>>>.>.
........<<....>>..<<<<<<.....<<.....>>....>>>>>>..
<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<
<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>
>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>
>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<
<<<.>>>>>>..>>>..................................<
<....>>...............<<<<....>>>>................
................<<<<<<<<.<<<<.<<...<<<<<<<<.<<<...
..<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<
<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<.
.>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>
>..........<<<<<<.<..>.<<<<<<.>>>>.>>.>>>>>>......
>>.>>>>>...>>>>>..>>>>>>>>>..<<<<....>>>><<<<<<...
.<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....
<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<.>>....>>>>>>
>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<.
...<.<<<....>>>.><<.<<<<<<<..<<<.<<<<<<<<...>>>>>>
...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<..>>>.>>>>.
...<<<......>>>...<<<<<<<...<<<(((.......<<<<<..))
)......>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>
>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....
>>>>>>>>...>>>>>>>>>>..>.....>>>>>>.<.....<......<
<<<.....<<<<<.>>>>>..>>>>.>....>.<<<<..>>>>....<<<
<<<.<..<<<....<<<<<.................>>>>>..<<<<...
.<<<<.....<..<<<<<<....>>>>>>....>....>>>>...>>>><
<<..>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<.....
...<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<
<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..........
....>>>>..>>>>>>>>.<<<<<.<.............>....<<<<<<
<<<<.....<<<<....<<<<<......>>>>>...>>>>....>>.>>>
>>.>>>..>>>>>..
Receptor-Ligand Complex Structure
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PDB8fkq Principles of human pre-60 S biogenesis.
Resolution2.76 Å
Binding residue
(original residue number in PDB)
G2 Y4 Q8 R12 K14 Q15 P40 R41 R44 K47 R49 R50 L51 K54 A55 K56 R68 L92 K93 F94 A95 R96 R108 W120 F138 R144 W150 H156 K157 H158 M161 R162 L164 S171 R172 K176 G177 H178 K179 H181 H182 I184 G186 R189 W192 R193 R194 R195 H201 R202 R204
Binding residue
(residue number reindexed from 1)
G1 Y3 Q7 R11 K13 Q14 P39 R40 R43 K46 R48 R49 L50 K53 A54 K55 R67 L71 K72 F73 A74 R75 R87 W99 F117 R123 W129 H135 K136 H137 M140 R141 L143 S150 R151 K155 G156 H157 K158 H160 H161 I163 G165 R168 W171 R172 R173 R174 H180 R181 R183
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045296 cadherin binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0045471 response to ethanol
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0031672 A band
GO:0044391 ribosomal subunit
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8fkq, PDBe:8fkq, PDBj:8fkq
PDBsum8fkq
PubMed37410842
UniProtP61313|RL15_HUMAN Large ribosomal subunit protein eL15 (Gene Name=RPL15)

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