Structure of PDB 5tcu Chain L1 Binding Site BS02

Receptor Information
>5tcu Chain L1 (length=109) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIK
RRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYY
LRSLRGKAA
Ligand information
>5tcu Chain B (length=2755) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauaugugaauacauagcauaucagaaggcacacccggagaacugaaaca
ucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggc
gagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguugua
ggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaag
augaaucaaagaagguaauaauccuguagucgaaaauguugucucucuug
aguggauccugaguacgacggagcacgugaaauuccgucggaaucuggga
ggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccagu
accgugagggaaaggugaaaagcaccccggaaggggagugaaauagaacc
ugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgu
gccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagca
guaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauu
uggucguagacccgaaaccaggugaucuacccuuggucagguugaaguuc
agguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcgg
augaacugaggguagcggagaaauuccaaucgaaccuggagauagcuggu
ucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggaggu
agagcacuguuuggacgaggccgaauucagacaaacuccgaaugccaauu
aauuuaacuugggagucagaacaugggugauaagguccguguucgaaagg
gaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaa
aaggauguggcguugcccagacaacuaguagucgagugacacugcgccga
aaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuugga
caaugguaggagagcguucuaagggcguugaagcaugaucguaaggacau
guggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggug
agaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgc
ucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggau
aacagguugauauuccuguaccaccuauaaucgaucgauggggggacgca
guaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcu
gaguaauccgguacucgggcugagcugugauggggagaagacucuucgag
ucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcc
cguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcg
agcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggag
aaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcc
caagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugau
guauaggggcugacgccugcccggugcuggaagguuaagaggagugguua
gcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacua
uaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgca
cgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaau
cauaguaccugugaagaugcagguuacccgcgacaggacggaaagacccc
guggagcuuuacuguagccugauauugaaauucggcacagcuagcugugu
uggcuuucuaacccgcaccacuuaucguggugggagacagugucaagcgg
gcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaa
gguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagg
gagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuua
gugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcu
accccggggauaacaggcuuaucucccccaagaguucacaucgacgggga
gguuuggcaccucgaugucggcucaucgcauccuggggcuguagucgguc
ccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucag
aacgucgugagacaguucggucccuauccgucgugggcguaggaaauuug
agaggagcuguccuuaguacgagaggaccgggauggacauaccucuggug
uaccaguugucgugccaacggcauagcuggguagcuauguguggacggga
uaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucc
caacuucgguuauaagaucccucaaagaugaugagguuaauagguucgag
guggaagcauggugacauguggagcugacgaauacuaaucgaucgaagac
uuaau
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.>.......>>>>.>.........<<....>>...<<<<......<<...
..>>.....>>>>...(((....<<<<<<<<....>>>>>>>>.......
<<<<<<<<...<.<........<..<<<<<<.<<<...<<<<<......>
>>>>((......<<<.....))>>>...>>>...>>>>>>...>.>.>.>
>>>>..>>>......<<<<<<<<.........>>>>>>>>......<<<<
<..<<<<>>>>>..)))......]].>>>>>>>.]]..............
.<<....>>....]].........<<<<....>>>>..............
....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>..
.<.<........>.>.<<<<<<....<<<<<<<.<<<<...<<<...<<<
.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>
.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<
<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>
....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>.
.<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<....
.<<<...<<<<<<<<..........>>>>>>>>..>>.>.....>>>>.>
>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<
<......>>>...<<<<.<<<...<<<(((.....<<<<<<.........
..<<..<<<..<<<<........<<<...>>>....>>>>..>>>.>>..
.........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>
>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>
>>...>>.>>>>>>>........>>>>>><......<.....<<<<<<..
.....>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>
>>>>>.....(<<<<.<<...<<<...<<<....>>>...>>>...>>..
.<<<<..........>>>>).<<<<<<.......<<...<<......<<<
<...<<...<....<.<<<.....{...>>>.>.<....<<<<<..<<<.
..................>>>..>>>>>.....>................
....>....>>...>>>.>..........>>..>>.......>>>>>>>>
>>.>>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<
<<....<<<<<<<<.<<...............<<<<<....<....>...
..>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<
<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>...
....>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.
.<....>...>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....
>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<
<.[.<<<<..<<<<<.<<.<<<<<<.<<<<.<<<<<<<<<<..>>>>>>>
>>>.>>>>....<<.<<<<<.......>>>>>>>.....>>>>>>.>>..
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>
>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]
......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>
...]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>
>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>
>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<
<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<..
.<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<.
..<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<.
<..<<<<.............>>>>...>>>>.>>>>.......>>>>>>>
.<<......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<
<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>
>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tcu Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.
Resolution3.9 Å
Binding residue
(original residue number in PDB)
T2 H4 R23 R53 G54 G55 S58 R95 R96 A97 K98 Y100
Binding residue
(residue number reindexed from 1)
T1 H3 R22 R52 G53 G54 S57 R94 R95 A96 K97 Y99
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5tcu, PDBe:5tcu, PDBj:5tcu
PDBsum5tcu
PubMed28487427
UniProtQ2FZ42|RL19_STAA8 Large ribosomal subunit protein bL19 (Gene Name=rplS)

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