Structure of PDB 5t7v Chain L1 Binding Site BS02

Receptor Information
>5t7v Chain L1 (length=113) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKR
RGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYL
RSLRGKAARIQEI
Ligand information
>5t7v Chain B (length=2768) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gauuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgau
gaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuu
gauccagagauuuccgaauggggaaacccagcaugaguuaugucauguua
ucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaa
caucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcg
gcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguug
uaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaa
agaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucu
ugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugg
gaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaacca
guaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaa
ccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggc
gugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaag
caguaaauguggagccguagcgaaagcgagucugaauagggcguuuagua
uuuggucguagacccgaaaccaggugaucuacccuuggucagguugaagu
ucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagc
ggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcug
guucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggag
guagagcacuguuuggucagacaaacuccgaaugccaauuaauuuaacuu
gggagucagaacaugggugauaagguccguguucgaaagggaaacagccc
agaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugg
cguugcccagacaacuggagugcguaauagcucacuagucgagugacacu
gcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguc
cuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucgua
aggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaag
acgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcu
cguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggc
gauggauaacagguugauauuccuguaccaccuauaaucguaucgauggg
gggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagca
guaaggcugaguaauccgguacucgggcugagcugugauggggagaagac
auugugucuucgagucguugauuucacacugccgagaaaagccucuagau
agaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaa
uucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccc
cguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagcc
gcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcua
aaccguaaggugauguauaggggcugacgccugcccagugcuggaagguu
aagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaac
ggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgggua
aguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgag
agacucggugaaaucauaguaccugugaagaugcagguuacccgcgacag
gacggaaagaccccguggagcuuuacuguagccugauauugaaauucggc
acagcuagcuguguuggcuuucuaacccgcaccacuuaucguggugggag
acagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaa
cggaggcgcucaaagguucccucagaaugguuggaaaucauucauagagu
guaaaggcauaagggagcuugacugcgagaccuacaagucgagcaggguc
gaaagacggacuuagugauccggugguuccgcauggaagggccaucgcuc
aacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguu
cacaucgacggggagguuuggcaccucgaugucggcucaucgcauccugg
ggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacg
cgagcuggguucagaacgucgugagacguucggucccuauccgucguggg
cguaggaaauuugagaggagcuguccuuaguacgagaggaccgggaugga
cauaccucugguguaccaguugucgugccaacggcauagcuggguagcua
uguguggacgggauaagugcugaaagcaucuaagcaugaagccccccuca
agaugagauuucccaacuucgguuauaagaucccucaaagaugaugaggu
uaauagguucgagguggaagcauggugacauguggagcugacgaauacua
aucgaucgaagacuuaau
..<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<...
...<<.<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>...
..>>>>>>>....>>....<<<....>>>.<<<<<<......>>>>>>..
<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<...
...>.......>>>>.>.........<<....>>..<<<<<......<<.
....>>.....>>>>>..(((....<<<<<..........>>>>>.....
.<<<<<<<<<...<.........<<<..<<<<<.<<<...<<<<<.....
.>>>>>((......<<<.....))>>>...>>>.>..>>>>..>>>...>
.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<
<<<..<<<<>>>>>..)))......]].>>>>>>>.]]............
...<<....>>....]].........<<<......>>>............
.}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>
...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<
<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>
>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<
<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>
>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>
>..<<<<<<....<<<<<....>>>>><<.<<<<<<...<<<<<<<<<..
....<<...<<<<<<..>>>>>>..>>.......>>>>.>>>>>..>>>>
>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>
...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<
.<<<<........<<<.....<<......>>.....>>>....>>>>.>>
>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<
.....>>>>>>....>>>>>>..<<<<<<<.<.......<<<<<.<<...
.>>.>>>>>....>.>>>>>>>........>>>>>><......<.....<
<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<..
...>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>
..>>>....<<<<........>>>>.))<<<<<<<......<<<...<<<
<....<<<<...<<...<.......<<...[.....>>....<....<<<
<...<<<...................>>>...>>>>.....>.....<..
.........>........>....>>...>>>.>........>>>>..>>>
.....>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<......
.>>>..>>>>..<<<<....<<<<<<<..<<.........<.....<<<<
<.....<..>......>>>>><<<<<.<.<<<<....>>>>..>>>>>>.
...........<<<<<<<<<..<<<.........>>>..<<<<<<<....
.<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<
..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>
>>><<<<<<.......>>>>>>........<...........<<<<<...
....>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>..>>>>>
>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(
((.((......<<<<.((<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<
<.<<....>>.>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>..
...>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<....<<<<<<<...<<<<<<.......>>>>>>.....<<
.((.((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<
....>>>..>))))......<<<<<<<.((..>>>>..))>>>>>>>...
..........>>>>..))>>>>.......<<<<...<<<<<<...<<...
....>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<
<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>>..>
...>>>.>>....<<<<<<<....>>>>>>>....))..)))>>>>>>>>
....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.
<<<<<....<<<...<<<<<<<<<<....].>>>>>..>>>>>...>>>.
.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.
......>>>>>>>..<<....>>.....<<<<<<<<.........>>>>.
...<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>
...>>>>....>>>>>>.
Receptor-Ligand Complex Structure
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PDB5t7v Structural Basis for Linezolid Binding Site Rearrangement in theStaphylococcus aureusRibosome.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
N3 R23 K51 R52 S58 R95 R96 A97 K98 Y100
Binding residue
(residue number reindexed from 1)
N1 R21 K49 R50 S56 R93 R94 A95 K96 Y98
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5t7v, PDBe:5t7v, PDBj:5t7v
PDBsum5t7v
PubMed28487427
UniProtA0A077UVB6

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