Structure of PDB 8ftd Chain L Binding Site BS02

Receptor Information
>8ftd Chain L (length=470) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFVPELAREKFAELRAQYVVTRDTIA
TAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVE
QCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQK
LQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKK
YTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSI
ADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDK
IRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAA
THDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAK
ALRKLRHPSRSEVLRSFLDD
Ligand information
>8ftd Chain Q (length=56) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaatcagccccaatgtgtaataccagatttatgagcgccatgaccagc
ctcaat
Receptor-Ligand Complex Structure
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PDB8ftd General transcription factor from Escherichia coli with a distinct mechanism of action.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		T440 R562 E585 R588
Binding residue
(residue number reindexed from 1)		T297 R419 E442 R445
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ftd, PDBe:8ftd, PDBj:8ftd
PDBsum8ftd
PubMed38177674
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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