Structure of PDB 8eyz Chain L Binding Site BS02

Receptor Information
>8eyz Chain L (length=220) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLVVATDTAFVPFEFKQGDIYVGFDVDLWAAIAKELKLDYELKPMDFSGI
IPALQTKNVDLALAGITICDERKKAIDFSDGYYKSGLLVMVKANNNDVKS
VKDLDGKVVAVKSGTGSVDYAKANIKTKDLRQFPNIDNAYMELGTNRADA
VLHDTPNILYFIKTAGNGQFKAVGDSLEAQQYGIAFPKGSDELRDKVNGA
LKTLRENGTYNEIYKKWFGT
Ligand information
Ligand IDX5Z
InChIInChI=1S/C7H7N.2C4H8N2O2.Co.N3/c1-2-7-3-5-8-6-4-7;2*1-3(5-7)4(2)6-8;;1-3-2/h2-6H,1H2;2*7-8H,1-2H3;;/q;2*-2;+6;-1/b;2*4-3-;;
InChIKeyKKXSWROVWVQWSY-GLPMUSQESA-N
SMILES
SoftwareSMILES
ACDLabs 12.01C=Cc1cc[n+](cc1)[Co]12(\N=[N+]=[N-])(N(O)C(C)=C(C)N1O)N(O)C(C)=C(C)N2O
CACTVS 3.385CC1=C(C)N(O)[Co]2(N=[N+]=[N-])(N1O)(N(O)C(=C(C)N2O)C)[n+]3ccc(C=C)cc3
OpenEye OEToolkits 2.0.7CC1=C(N([Co]2(N1O)(N(C(=C(N2O)C)C)O)(N=[N+]=[N-])[n+]3ccc(cc3)C=C)O)C
FormulaC15 H23 Co N8 O4
NameAZIDOBIS (DIMETHYLGLYOXIMATO) PYRIDINECOBALT
ChEMBL
DrugBank
ZINC
PDB chain8eyz Chain L Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8eyz Engineering a Conformationally Switchable Artificial Metalloprotein.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		C72 D73 E74 D122 E181
Binding residue
(residue number reindexed from 1)		C69 D70 E71 D119 E178
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0070406 glutamine binding
Biological Process
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0034220 monoatomic ion transmembrane transport
GO:1903803 L-glutamine import across plasma membrane
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8eyz, PDBe:8eyz, PDBj:8eyz
PDBsum8eyz
PubMed36378237
UniProtP0AEQ3|GLNH_ECOLI Glutamine-binding periplasmic protein (Gene Name=glnH)

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