Structure of PDB 8asc Chain L Binding Site BS02

Receptor Information
>8asc Chain L (length=530) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEI
ALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQ
ADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSL
KKCDISLQFFLPFSLDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMV
MISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRI
AAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDII
QGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQV
LKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPH
IKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSM
SLAKKKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIW
NMLNPPAEVTTKSQIPLSKIKTLFPLIEAK
Ligand information
Receptor-Ligand Complex Structure
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PDB8asc PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		I245 K265 Y397 N402
Binding residue
(residue number reindexed from 1)		I234 K254 Y386 N391
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asc, PDBe:8asc, PDBj:8asc
PDBsum8asc
PubMed37256950
UniProtP13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)

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