Structure of PDB 7yev Chain L Binding Site BS02

Receptor Information
>7yev Chain L (length=1024) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANVWGVRLADSLSSPTIETRTRHYTLHDFYSDLDASVGKEPWRPLRNQRT
NEIVAVQLFRPLQGLVFDTQLYGFPGTFSQWEQFMKEKLRVLKYEVLRIY
PISTYNHDRVNVFVANALVGAFLSNQAFYDLLPLLIVNDTMISDLLGTGA
ALSQFFQSHGEVLEVAAGRKYLQMNNYSNDDDDPPLFAKDLSDYAKAFYS
DTYEVLDRFFWTHDSSAGVLVHYDKPTNGNHYILGTLTQMVSAPPHIINA
TDALLLESCLEQFAANVRARSAQPVTRLDQCYHLRWGAQYVGEDSLTYRL
GVLSLLATNGYQLARPIPKQLTNRWLSSFVSQVVSDGINETPLWPQERYV
QIAYDSPSVVDGATQYGYVRRNQLRLGMRISALQSLSDTPAPVQWLPQYT
IDQVAVDEGDAMVSQLTQLPLRPDYGSIWIGEALSYYVDYNRSHRVVLSS
ELPQLPDTYFDGDEQYGRSLFSLARKVGDRSLVKDTAVLKHAYQAIDPNT
GKEYLRAGQSVAYFGASAGHSGADQPLVIEPWMQGKISGVPPPSSVRQFG
YDVAKGAIVDLARPFPSGDYQFVYSDVDQVVDGHDDLSISSGLVESLLDS
CVHATAPGGSFVMKINFPTRTVWHYIEQKILPNVTSYMLIKPFVTNNVEV
FFVAFGVHQQSALTWTSGVYFFLVDHFYRYETLSAISRQLPSFGYVDDGS
SVTGIEIISIENPGFSNMTQAARVGISGLCANVGNARKSIAIYESHGARV
LTITSRRSPASARRKARLRYLPLIDPRSLEVQARTILPSNPVLFDNINGA
SPHVCLTMMYNFEVSSAVYDGDVVLDLGTGPEAKILELIPSTSPVTCVDI
RPTAQPNGCWNVRTTFLELDYLSDGWITGVRGDIVTCMLSLGAAAAGKSM
TFDAAFQQLVRVLTRSTANVLLIQVNCPTDVIRTIKGYLEIDQTNKRYKF
PKFGRDEPYSDMDSLERICRAAWPNCSITWVPLSYDLRWTKLALLESTTL
SSASVRIAELMYKYMPIMRIDIHG
Ligand information
Ligand IDSAM
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1
InChIKeyMEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
CACTVS 3.341C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
ACDLabs 10.04[O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H22 N6 O5 S
NameS-ADENOSYLMETHIONINE
ChEMBLCHEMBL1235831
DrugBank
ZINC
PDB chain7yev Chain L Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yev In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		G516 S518 G551 Y552 D577 V578 D579
Binding residue
(residue number reindexed from 1)		G515 S517 G550 Y551 D576 V577 D578
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.7.7.50: mRNA guanylyltransferase.
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004484 mRNA guanylyltransferase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0019028 viral capsid
GO:0039624 viral outer capsid

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yev, PDBe:7yev, PDBj:7yev
PDBsum7yev
PubMed36469786
UniProtC9E871

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