Structure of PDB 7v0s Chain L Binding Site BS02

Receptor Information
>7v0s Chain L (length=388) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRFTFPLMAIVLEIAMIVLFGLFVEYFELYPLFQDVHVMIFVGFGFLMTF
LKKYGFSSVGINLLVAALGLQWGTIVQGILQSQGQKFNIGIKNMINADFS
AATVLISFGAVLGKTSPTQMLIMTILEIVFFAHNEYLVSEIFKASDIGAS
MTIHAFGAYFGLAVAGILYRSGLRKGHENEESAYYSDLFAMIGTLFLWMF
WPSFNSAIAEPGDKQCRAIVNTYFSLAACVLTAFAFSSLVEHRGKLNMVH
IQNATLAGGVAVGTCADMAIHPFGSMIIGSIAGMVSVLGYKFLTPLFTTK
LRIHDTCGVHNLHGLPGVVGGLAGIVAVAMGASNTSMAMQAAALGSSIGT
AVVGGLMTGLILKLPLWGQPSDQNCYDDSVYWKVPKTR
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain7v0s Chain L Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7v0s Architecture of the human erythrocyte ankyrin-1 complex.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y180 L183 A184 R323 I324
Binding residue
(residue number reindexed from 1)		Y159 L162 A163 R302 I303
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008519 ammonium channel activity
GO:0015200 methylammonium transmembrane transporter activity
GO:0022840 leak channel activity
GO:0030506 ankyrin binding
GO:0035379 carbon dioxide transmembrane transporter activity
Biological Process
GO:0006873 intracellular monoatomic ion homeostasis
GO:0015670 carbon dioxide transport
GO:0015701 bicarbonate transport
GO:0035378 carbon dioxide transmembrane transport
GO:0048821 erythrocyte development
GO:0060586 multicellular organismal-level iron ion homeostasis
GO:0072488 ammonium transmembrane transport
GO:0072489 methylammonium transmembrane transport
GO:0097272 ammonium homeostasis
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0170014 ankyrin-1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7v0s, PDBe:7v0s, PDBj:7v0s
PDBsum7v0s
PubMed35835865
UniProtQ02094|RHAG_HUMAN Ammonium transporter Rh type A (Gene Name=RHAG)

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