Structure of PDB 7ssa Chain L Binding Site BS02

Receptor Information
>7ssa Chain L (length=67) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRKDSHKEVERRRRENINTAINVLSDLLPVRESSKAAILACAAEYIQKLK
ETDEANIEKWTLQKLLS
Ligand information
>7ssa Chain J (length=137) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caggatgtatatatctgagacgtccctggagactagggagtaatcccctt
ggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctag
agctgtctacgaccaattgagcggcctggtcacgtga
Receptor-Ligand Complex Structure
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PDB7ssa Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H227 E231 R234
Binding residue
(residue number reindexed from 1)		H6 E10 R13
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0019237 centromeric DNA binding
GO:0046983 protein dimerization activity
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007059 chromosome segregation
GO:0042762 regulation of sulfur metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061431 cellular response to methionine
GO:1900059 positive regulation of sulfate assimilation
GO:1900060 negative regulation of ceramide biosynthetic process
GO:1900090 positive regulation of inositol biosynthetic process
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005739 mitochondrion
GO:0089713 Cbf1-Met4-Met28 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ssa, PDBe:7ssa, PDBj:7ssa
PDBsum7ssa
PubMed36996811
UniProtP17106|CBF1_YEAST Centromere-binding protein 1 (Gene Name=CBF1)

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