Structure of PDB 7ojl Chain L Binding Site BS02

Receptor Information
>7ojl Chain L (length=1498) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNR
LRKGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPI
LRFLYANIGKECQMQYWRSFLNKVKSLRILNTRRKLLLIFDALILLASIH
DQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERPPDKN
QILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDVSG
VVPTISYQRTEDEKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSSTV
KLRQNEFGPARYQVVRCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAIND
NRVGEICSFYADPKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLCNI
NSLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLREEL
ITDVEFLLYRLVRALVNLILSEDVKSMMTNRFKFILNISYMCHFITKETP
DRLTDQIKCFEKFLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLSKE
GCTSIKGPDYKKPGVSKRFLSLLTSSFNNGSLFKESEVKREIKDPLVLDL
ASNKSVVVNKYTDGSRVLNYDFNKLTALAVSQLTEVFSRKGKHLLNKQDY
DYKVQQAMSNLVLLLDGGASVYFDQLKETVERIIDQYRQPSVNDLDEVVP
NKFYIRLIKGELSNHMVEDFDYDVLPGNFYEEFCDAVYKNNKLKERYFYC
GTKAVATRTYFDQEYFQCFKSILLIMNANLNFKFDMGRLSDDVRISERES
NSEALSKALSLTNLKNLCFYSQESPQSYSSTGPDTGRLKFSLSYKEQVGG
NRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEREFENAILSMKLN
VSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFLSKDLQADIKGRDYLST
LLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLKKKTTQSITEDFFYSNFQI
GVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICGGTIDAYTS
SDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVSPKSVIGRF
VAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIIDQSVA
NGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVDGNRSYRIM
RQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSEHLSSLSNL
CELLGVEPPSESDLEFSWLNLAAHHPLRMVLRQKIIYEKVPTIVKTIQNK
LSFQSSIASGFVGLCRTLGSKCVRGPNKESLYIKSIQSLISDIQGIEPLI
DSHGVQYWRVPLNIRDGNEGVISYFRPLLWDYMCISLSTAIELGAWVLGE
PKKVRVLEFFKHNPCDYFPLKPAAVGLNHIIHSLRRLYPSVFEKHILPFM
RIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSSELRLSHTRTH
Ligand information
>7ojl Chain D (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgcaccggggauccuaggc
.<.....>............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ojl Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		P297 T341 S470 Y471 Q472 T474 S512 T513 V514 K515 Q518 E520 R525 Y526 V529 Q551 K552 S557 C559 S572 Y574 S630 R632 I665 D715 I721 K722 K861 K1255 K1263 T1265
Binding residue
(residue number reindexed from 1)		P99 T132 S256 Y257 Q258 T260 S298 T299 V300 K301 Q304 E306 R311 Y312 V315 Q337 K338 S343 C345 S358 Y360 S416 R418 I451 D501 I507 K508 K640 K976 K984 T986
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ojl, PDBe:7ojl, PDBj:7ojl
PDBsum7ojl
PubMed34857749
UniProtA0A3S8NV63

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