Structure of PDB 7ojk Chain L Binding Site BS02

Receptor Information
>7ojk Chain L (length=1843) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EIDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGV
ESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLR
KGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILR
FLYANIGEGIKECQMQYWRSFLNKVKSLRILNTRRKLLLIFDALILLASI
HDQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERSPPD
KNQILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDV
SGVVPTISYQRTEDEKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSS
TVKLRQNEFGPARYQVVRCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAI
NDNRVGEICSFYADPKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLC
NINSLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLRE
ELITDVEFLLYRLVRALVNLILSEDVKSMMTNRFKFILNISYMCHFITKE
TPDRLTDQIKCFEKFLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLS
KEGCTSIKGPDYKKPGVSKRFLSLLTSSFNNGSLFKESEVKREIKDPLVK
SVVVNKYTDGSRVLNYDFNKLTALAVSQLTEVFSRKGKHLLNKQDYDYKV
QQAMSNLVLGPADLDEILLDGGASVYFDQLKETVERIIDQYDQPSVNDLD
EVVPNKFYIRLIKGELSNHMVEDFDYDVLPGNFYEEFCDAVYKNNKLKER
YFYCGTKAVATRTYFDQEYFQCFKSILLIMNANNFKFDMGRLSDDVRISE
RESNSEALSKALSLTNCTTAMLKNLCFYSQESPQSYSSTGPDTGRLKFSL
SYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEREFEN
AILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFLSKDLQADI
KGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLKKKTTQSITED
FFYSNFQIGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICG
GTIDAYTSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVS
PKSVIGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETID
TIIDQSVANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVD
GNRSYRIMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSE
HLSSLSNLCELLGVEPPSESDLEFSWLNLAAHHPLRMVSSIASGFVGLCR
TLGSKCVRGPNKESLYIKSIQSLISDIQGIEPLIDSHGVQYWRVPLNIRD
GNEGVISYFRPLLWDYMCISLSTAIELGAWVLGEPKKVRVLEFFKHNPCD
YFPLKPAAGLNHIIHSLRRLYPSVFEKHILPFMSDLASTKMKWSPRIKFL
DLCVALDVNCREEHYIVLSSELRLSHTRTHTSDAVDNFMRQIYFESYVRS
FVATTRTLGSFTWFPHKTSVPEGEGLQRLGPFSSFVEKAIHKGIERPMFK
HDLMPVPLVVHRSGLWECDKKLASFTPVVQDQDLEMFVKEVGDSSLDLLI
GALSAMILDRLKLRMQWSEVDIVSMLKAAMPSNSVKVLNAVLE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ojk Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution3.89 Å
Binding residue
(original residue number in PDB)		Y471 S512 T513 Q518 R525 Y526 Q551 K552 S557 K558 Y574 K861
Binding residue
(residue number reindexed from 1)		Y459 S500 T501 Q506 R513 Y514 Q539 K540 S545 K546 Y562 K836
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ojk, PDBe:7ojk, PDBj:7ojk
PDBsum7ojk
PubMed34857749
UniProtA0A3S8NV63

[Back to BioLiP]