Structure of PDB 7oea Chain L Binding Site BS02

Receptor Information
>7oea Chain L (length=1432) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDDMACVKDLVSKYLADNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCIE
IDSCNANGCEHNSEDKSVERILHDHGILTPSLCFVVPDGYKLTGNVLILL
ECFVRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNEQ
IPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMSGVESLNVL
LDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLRKGEITG
QFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPILRFLYANI
GEKECQMQYWRSFLNKVKSLRILTRRKLLLIFDALILLASIHDQTRHKCS
KGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERSNTIQPPDKNQIL
ISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDVSGVVP
TISYQRTKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSSTVQVVRCK
EAYCQEFLLSGAEFQLIYQKTGECSKCYAINDNRVGEICSFYADPKRYFP
AIFSAEVLQTTVSTMISWVKDCSELEEQLCNINSLTKMILVLILAHPSKR
SQKLLQNLRYFIMAYVSDYHHKDLIDKLREELITDVEFLLYRLVRALVNL
ILSEDVKSMMTNRFKFILNISYMCHFITKETPDRLTDQIKCFEKFLEPKL
EFGHVSINPADVATEEELDDMVYNAKKFLSKEGCTSIKGPDYKKPGVSKR
FLSLLTSSFNNGSLFKESEVTTAMLKNLCFYSQESPQSYSSTGPDTGRLK
FSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNERE
FENAILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFQADIKG
RDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGTTQSITEDFFYSNF
QIGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICGGTIDAY
TSSDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVSPKSVIG
RFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIIDQS
VANGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVDGNRSYR
IMRQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSEHLSSLS
NLCELLGVEPPSESDLEFSWLNLAAHHPLRMVPTIVKTIQNKLSSTFTRG
AQKLLSEAINKSAFQSSIASGFVGLCRTLGSKCVRGPNKESLYIKSIQSL
ISDIQGIEPLIDSHGVQYWRVPLNIRDGNEGVISYFRPLLWDYMCISLST
AIELGAWVLGEPKKVRVLEFFKHNPCDYFPLKPAAIKFLDLCVALDVNCE
ALSLVSHIVKKREEHYIVLSSELRLSHTRTHE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7oea Chain L Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oea Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		H364 C366
Binding residue
(residue number reindexed from 1)		H347 C349
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oea, PDBe:7oea, PDBj:7oea
PDBsum7oea
PubMed34857749
UniProtA0A3S8NV63

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