Structure of PDB 6s6x Chain L Binding Site BS02

Receptor Information
>6s6x Chain L (length=472) Species: 192 (Azospirillum brasilense) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRMLGFVHTAQRMPDKRPAAERRQDFAEIYARFSDERANEQANRCSQCGV
PFCQVHCPVSNNIPDWLKLTSEGRLEEAYEVSQATNNFPEICGRICPQDR
LCEGNCVIEQSTHGAVTIGSVEKYINDTAWDQGWVKPRTPSRELGLSVGV
IGAGPAGLAAAEELRAKGYEVHVYDRYDRMGGLLVYGIPGFKLEKSVVER
RVKLLADAGVIYHPNFEVGRDASLPELRRKHVAVLVATGVYKARDIKAPG
SGLGNIVAALDYLTTSNKVSLGDTVEAYENGSLNAAGKHVVVLGGGDTAM
DCVRTAIRQGATSVKCLYRRDRKNMPGSQREVAHAEEEGVEFIWQAAPEG
FTGDTVVTGVRAVRIHLGVADATGRQTPQVIEGSEFTVQADLVIKALGFE
PEDLPNAFDEPELKVTRWGTLLVDHRTKMTNMDGVFAAGDIVRGASLVVW
AIRDGRDAAEGIHAYAKAKAEA
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6s6x Chain L Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6s6x Cryo-EM Structures of Azospirillum brasilense Glutamate Synthase in Its Oligomeric Assemblies.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		C60 V62 N64 C99 C105 I121 E125
Binding residue
(residue number reindexed from 1)		C57 V59 N61 C96 C102 I118 E122
Annotation score1
Enzymatic activity
Enzyme Commision number 1.4.1.13: glutamate synthase (NADPH).
Gene Ontology
Molecular Function
GO:0004355 glutamate synthase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006537 glutamate biosynthetic process
GO:0097054 L-glutamate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6s6x, PDBe:6s6x, PDBj:6s6x
PDBsum6s6x
PubMed31473159
UniProtQ05756|GLTD_AZOBR Glutamate synthase [NADPH] small chain (Gene Name=gltD)

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