Structure of PDB 6r90 Chain L Binding Site BS02

Receptor Information
>6r90 Chain L (length=365) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPF
DRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSIT
GLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVS
ASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLAT
ASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKS
EIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPN
FKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA
MGYHILIWSQEEART
Ligand information
>6r90 Chain J (length=145) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatccacctgcagattctaccaaaagtgtatttggaaactgctcc
atcaaaaggcatgttcagctgaaccagctgaacatgccttttcctggagc
agtttccaaatacacttttggtagaatctgcaggtggatattgat
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6r90 DNA damage detection in nucleosomes involves DNA register shifting.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		R112 K132 A155 M177 W203 K244 V263 Q308 H333 Q335 H336
Binding residue
(residue number reindexed from 1)		R52 K72 A95 M117 W143 K184 V203 Q248 H273 Q275 H276
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006290 pyrimidine dimer repair
GO:0006974 DNA damage response
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0034644 cellular response to UV
GO:0051865 protein autoubiquitination
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0030054 cell junction
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0032991 protein-containing complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
GO:0090734 site of DNA damage

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6r90, PDBe:6r90, PDBj:6r90
PDBsum6r90
PubMed31142837
UniProtQ92466|DDB2_HUMAN DNA damage-binding protein 2 (Gene Name=DDB2)

[Back to BioLiP]