Structure of PDB 6psq Chain L Binding Site BS02

Receptor Information
>6psq Chain L (length=551) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQLKLLVTRGKEQGYLTYAEVNDHLPEDIVDSDQIEDIIQMINDMGIQVM
EEAPDADDLMNTADEDAAEAAAQVLSSVESEIGRTTDPVRMYMREMGTVE
LLTREGEIDIAKRIEDGINQVQCSVAEYPEAITYLLEQYDRVEAEEARLS
DLITGFVDPELAREKFAELRAQYVVTRDTIATAQEEILKLSEVFKQFRLV
PKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLFTGNETS
DTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDIN
RRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGL
MKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINK
LNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIG
DDEDSHLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMR
FGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLD
D
Ligand information
>6psq Chain P (length=50) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaaggccgaggaatatgcccttttagccttcttttgtcaatggatttgtg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6psq Stepwise Promoter Melting by Bacterial RNA Polymerase.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		T429 R436 K462 R465 R562 L573 R584 E585 R588
Binding residue
(residue number reindexed from 1)		T367 R374 K400 R403 R500 L511 R522 E523 R526
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6psq, PDBe:6psq, PDBj:6psq
PDBsum6psq
PubMed32160514
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

[Back to BioLiP]